MedicationsTreatment for lupus depends on your signs and symptoms. It is always important to discuss with your doctor the benefits and side effects of these medications. The medications that are most commonly used include: 1. Nonsteroidal anti-inflammatory drugs (NSAIDs).Over-the-counter NSAIDs, such as naproxen sodium (Aleve) and ibuprofen (Advil, Motrin IB), may be used to treat pain, swelling and fever. Side effects: stomach bleeding, kidney problems, and increased risk of heart problems. 2. Antimalarial drugs. Medications commonly used to treat malaria, such as hydroxychloroquine (Plaquenil) can help control lupus. Side effects: stomach upset and very rarely damage to the retina of the eye. 3. Corticosteroids- Prednisone is one of the medications used to reduce inflammation. Long term Side effects: Weight gain, easy bruising, thinning bones (osteoporosis), high blood pressure, diabetes and increased risk of infection. The risk of side effects increase with higher doses and longer term therapy. 4. Anticoagulants- Because blood clots can be a life-threatening symptom of lupus, these drugs thin the blood to prevent it from clotting too easily. Anticoagulant medications include low-dose aspirin and prescription heparin (Calciparine, Liquaemin) and warfarin (Coumadin). In particular, if you are being treated with warfarin, you must be monitored by your doctor to be sure your blood does not become too thin. Anticoagulant therapy may be lifelong in some people with lupus. Side effects: Bleeding, Dizziness or weakness, Nausea, vomiting. 5. Immunosuppressants- Drugs that suppress the immune system may be helpful in serious cases. Examples include azathioprine (Imuran, Azasan), mycophenolate (CellCept), leflunomide (Arava) and methotrexate (Trexall). Potential side effects may include an increased risk of infection, liver damage, decreased fertility and an increased risk of cancer. A newer medication, belimumab (Benlysta), also reduces lupus symptoms in some people. Side effects: nausea, diarrhea and fever. Cyclophosphamide (Cytoxan)
Azathioprine (Imuran)
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